The Clinical and Scientific Basis of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome

The Clinical and Scientific Basis of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome
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M.E. Epidemics

1.  Los Angeles City and California State, USA
Epidemic among personnel at L.A. County Hospital, Ruth Protection Home and throughout California, paralleling poliomyelitis, often diagnosed as atypical poliomyelitis, sometimes including arthropathy.

2.  Fond-du-Lac, Wisconsin, USA

An outbreak of “encephalitis” in St. Agnes Convent.

3.  Erstfeld, Switzerland
Outbreak described as “Abortive Poliomyelitis.”

4.  St. Gallen, Switzerland
Outbreak in Frohburg Hospital described as “Abortive Poliomyelitis.”

5.  Middlesex, England
Outbreak at Harefield Sanatorium – “Persitent myalgia following sore throat.”

6.  Degersheim, St. Gallen, Switzerland
Outbreak described as “Abortive Poliomyelitis.”

7.  University Hospital of Pennsylvania, USA
Epidemic described as “pleurodynia with  prominent neurological symptoms and no demonstrable cause.”

8.  Iceland

“Mixed epidemics of poliomyelitis and a disease resembling poliomyelitis with the character of the Akureyri Disease.”

9.  North Coast Towns, Iceland

“A disease epidemic in Iceland simulating Poliomyelitis” in three separate towns during this time.

10.  Adelaide, South Australia

Outbreak of a disease resembling poliomyelitis.

11.  Louisville, Kentucky, USA

Outbreak in the Nurse’s Training School of St. Joseph Infirmary, later described as “epidemic neuromyasthenia.”

12.  Upper New York State
Outbreak described as resembling the “Iceland Disease…simulating Acute Anterior Poliomyelitis.”

13.  London, England

Outbreak at Middlesex Hospital Nurses’ Home described as “Encephalomyelitis associated with Poliomyelitis Virus.”

14.  Copenhagen, Denmark
Outbreak described as “epidemic myositis.”

15.  Lakeland, Florida, USA
Outbreak described as epidemic neuromyasthenia.

The Clinical and Scientific Basis of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome

16.  Coventry and Coventry District, England

“An illness resembling Poliomyelitis observed in nurses.”

17.  Rockville, Maryland, USA
Chestnut Lodge Hospital student nurses described with poliomyelitis-like epidemic neuromyasthenia.

18.  Jutland, Denmark
Outbreak of “Epidemic encephalitis with vertigo.”

19.  Tallahassee, Florida, USA

Bond JO.  A new clinical entity?  Lancet 1956; 2:256.

20.  Seward, Alaska
Outbreak described as “Benign Myalgic Encephalomyelitis (Iceland Disease).”

21.  Berlin, Germany
Among the British Army, a “further outbreak of a disease resembling poliomyelitis.”

22.  Liverpool, England
Outbreak among medical and nursing staff in a Liverpool Hospital.

23.  Dalston, Cumbria, England

“…an unusual disease seen in epidemic and sporadic form in general practice in 1955 and subsequent years.”

24.  London, England
Famous outbreak of benign myalgic encephalomyelitis among Royal Free Hospital staff.

25.  Perth, Western Australia
“Virus epidemic in recurrent waves.”

26.  Gilfach Goch, Wales
Outbreak of Benign encephalomyelitis.

27.  Durban and Durban City, South Africa
Outbreak among nurses at Addington Hospital called “The Durban Mystery Disease” describing neuromuscular dysfunction, and epidemic myalgic encephalomyelopathy, including sporadic cases in Johannesburg of a outbreak resembling poliomyelitis.

28.  Segbwema, Sierra Leone
An outbreak of encephalomyelitis.

29.  Patreksfordur and Thorshofn, Iceland
Unusual response to poliomyelitis vaccination.

30.  North West London, England
Outbreak of acute infective encephalomyelitis simulating poliomyelitis among a residential home for nurses.

31.  Ridgefield, Connecticut, USA
An epidemic of neuromyasthenia.

32.  Punta Gorda, Florida, USA
An outbreak of epidemic neuromyasthenia.

33.  Newton-le-Willows, Lancashire, England
Outbreak described as “lymphocytic meningo-encephalitis with myalgia and rash,” “An outbreak of a disease believed to have been cause by Echo 9 virus,” with other varying descriptions.

34.  Pittsfield, Williamstown, Massachusetts, USA
Outbreak of “epidemic neuromyasthenia” later described as benign myalgic encephalomyelitis.  (Included in this summary are sporadic cases in Hygiea, Sweden, with descriptions of encephalitis, meningitis or poliomyelitis; Coxsackie B and Echo Virus infections; benign myalgic encephalomyelitis.)

35.  Coventry, England

Outbreak described as epidemic malaise and benign myalgic encephalomyelitis.

36.  Brighton, South Australia

Outbreak described as “Coxsackie, Echo Virus meningitis and mylagic encephalomyelitis”, “Epidemic myalgic encephalomyelitis,” and “Benign myalgic encephalomyelitis.”

37.  Athens, Greece

An outbreak of benign myalgic encephalomyelitis in a nurse’s school, “periostitis and arthropathy noted.”  (Included in this summary is an outbreak of benign myalgic encephalomyelitis in Switzerland.)

S.W. London, England

Reports of sporadic cases of myalgic encephalomyelitis.

38.  Newcastle upon Tyne, England

Outbreak of benign myalgic encephalomylitis.

N.W. London, England
Reports of sporadic cases of influenza-like illness

Article describing sporadic cases and “The psychiatric sequelae of Benign Myalgic Encephalomyelitis.”

Basel, Switzerland

Sporadic case of benign myalgic encephalomyelitis described.

39.  New York State, USA

Outbreak described as epidemic neuromyasthenia in a convent in New York State.

40.  N.W. London, England

Outbreak described as epidemic malaise and epidemic neuromyasthenia.

41.  Franklin, Kentucky, USA
Outbreak of “neurmyasthenia” in a Kentucky factory, possibly due to mercury exposure.

The Clinical and Scientific Basis of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome

42.  Galveston County, Texas, USA

Outbreak described as “Epidemic Neuromyasthenia Variant?” and “Epidemic Diencephalomyelitis,” the latter describing neuropsychiatric, cardiovascular and endocrine disorders.

Edinburgh, Scotland

Sporadic cases resembling benign myalgic encephalomyelitis.

43.  Fraidek, Lebanon

Report on an epidemic of benign myalgic encephalomyelitis.

44.  State University of New York, USA

Medical Centre – report of epidemic Neuromyasthenia and “unidentified symptom complex.”

45.  Lackland Air Force Base, Texas, USA

Epidemic Neuromyasthenia reported.  “A syndrome or disease?”

46.  London, England

An outbreak of “epidemic neuromyasthenia” among nurses a the Hospital for Sick Children, Great Oromond Street.

47.  Sacramento, California, USA

“200 hospital staff in the [Mercy San Juan Hospital] fell ill in August September 1975.  The epidemic appears to have spread to the children of the hospital staff and from there to the children’s teachers.  43 have been seriously disabled with chronic illness from 1975-1992” [at publication of this text].

48.  Southwest Ireland

Reports on Mylagic Encephalomyelits and epidemic neuromyasthenia in this region.

49.  Dallas-Fort Worth, Texas, USA

“Epidemic Neuromyasthenia” reported.

[Ed. note: Dr. Hyde’s text notes that the first major M.E./CFS Symposium was held at the Royal Society of Medicine in London in this year.  M.E. aka epidemic neuromyasthenia, viral relationships to this disease, biochemical abnormalities in patients and other subjects were discussed by experts such as Shelokov, Ramsay, Richardson, Behan, Parish and others.]

50.  Southampton, England
Outbreak of M.E. in a girls’ school.

51.  West Kilbridge, Ayrshire, Scotland

M.E. epidemic reported in a rural medical practice.

52.  Helensburgh, Scotland

Coxsackie B outbreak reported in a general practice.

Stirlingshire, Scotland
Sporadic cases of M.E. reported.

53.  West Otago, New Zealand

Outbreak first described and an “unexplained illness,” later as M.E.  Included here are outbreaks in Dunedin and Hamilton New Zealand.

“From 1984 until 1992 [at publication of this text] an endemic period occurred in which an usually large number of cluster and epidemics of M.E./CFS have been recognized in North America.  After an apparent initial increase in the morbidity in 1983 there seemed to have appeared in late summer of 1984 an unprecedented increase of sporadic and epidemic cases across North America.  Although certain geographical hot spots seen to have taken up much of the medical interest, this endemic situation probably represents an unusual and unremitting morbidity in all areas of the United States and Canada.” -Dr. Byron Hyde-

54.  Incline Village, Lake Tahoe, Nevada, USA
“A chronic illness characterized by fatigue, neurlogic and immunologic disorders and active human herpesvirus type 6 infection.”  “This community epidemic, apparently started in a girls’ basketball team, then involved primarily teacher in at lest three high schools, and then large numbers of the community.”

55.  Chapel Hill, North Carolina, USA
“Epidemic amongst members of The North Carolina Symphony Orchestra.  Low NKC [Natural Killer Cells] associated with high yield of lymphoma, astrocytoma, glioma.”

56.  Montreal, Quebec-Ontario, Canada
“Over 500 cases of M.E./CFS documented during August-November 1984 period.  This endemic was active in all parts of Canada during this period and appears [to] have maintained its activity until the time of writing in 1991.”

57.  Truckee, California, USA
M.E. epidemic involving teachers and students.

58.  Lyndonville, New York, USA
M.E. epidemic in a rural community involving children and adults.

59.  Yerington, Nevada, USA
“In the same area [not far from Truckee, California] an M.E./CFS-like epidemic reputedly occurred in a reservation of American Native people.”

60.  Placerville, California, USA
“Outbreak of chronic fatigue syndrome ‘coincident with a heavy contamination of the local unfiltered water supply’.”

61.  Sonora, California, USA
“More than 35 children and adults were diagnosed with M.E. in the mountain country 100 miles from Lake Tahoe.  Many of these patients were associated in some way with Columbia Community College.”

62.  Roseville, California, USA
Rosedale Hopital reported 11 cases of M.E./CFS among staff.

63.  Elk Grove, California, USA
M.E. epidemic among teachers and students.